The SARM1 targeting therapeutics market is projected to grow at a CAGR of 102.1%, during the period 2033-2040, claims Roots Analysis

SARM1 inhibitors, having demonstrated the ability to prevent axonal degeneration, are being evaluated for the treatment of a number of neurodegenerative disorders. Once approved, these therapies are likely to capture a significant market share

Roots Analysis has announced the addition of “SARM1 Inhibitors Therapeutics Market, 2022 – 2040” report to its list of offerings.

Presently, several industry and non-industry stakeholders are evaluating SARM1 inhibitors as potential therapeutic agents for the treatment of neurological disorders across various preclinical studies and early stages of clinical development, worldwide. With the ongoing pace of innovation in this field, increasing R&D activity and promising pre-clinical data, several promising leads are anticipated to be commercially launched over the coming decade and SARM1 targeting therapeutics market is anticipated to witness substantial growth in the mid to long-term.

Key Market Insights

Presently, several SARM1 targeting therapy candidates are being developed by various industry players
About 65% of the pipeline candidates are currently being evaluated in the preclinical stages of development, followed by those currently in the discovery stage (35%). Further, it is worth mentioning that close to 85% of the SARM1 inhibitors are small molecules.

Currently, a number of companies claim to be engaged in the development of SARM1 inhibitors
The SARM1 inhibitors market is dominated by the presence of large companies (81%), followed by small players (19%). In addition, around 20% of the players were established post-2010.

120+ articles related to SARM1 inhibitors have been published between 2011 and 2022
Majority (81%) of the articles published in this domain were research papers, followed by review papers (12%). It is important to note that more than 70% of the total number of articles were published post-2018.

Over 30 grants have been awarded for research related to SARM1 inhibitors, since 2014
Close to 40% of the total amount was awarded under the R01 mechanism (which supports research projects). Further, genetics and neurology emerged as the key research departments, having received 34% of the total grants, each.

70+ patents related to SARM1 targeting therapeutics have been filed / granted till 2022
Over the years, the number of patents filed for SARM1 inhibitors has increased gradually; majority of the patents have been filed / granted in 2021. Most of the patents in this domain are patent applications (96%), followed by granted patents (3%).

North America is anticipated to capture more than 65% share of the market, by 2040
By 2040, the market revenues are likely to be driven by the sales of small molecules (95%) being developed as SARM1 inhibitors. Further, sales of therapeutics targeting multiple sclerosis are likely to contribute to a majority share (~40%) of revenues, in the long term.

To request a sample copy / brochure of this report, please visit
https://www.rootsanalysis.com/reports/sarm1-inhibitors-market/request-sample.html

Key Questions Answered
 Who are the leading players engaged in the development of SARM1 targeting therapeutics?
 What is the evolving trend of publications focused on SARM1 targeting therapeutics?
 How is the intellectual property landscape in this field likely to evolve in the foreseen future?
 What are the recent developments and strategic initiatives undertaken by players engaged in this market space related to the research and development of SARM1 targeting therapeutics?
 What are the key value drivers that are likely to influence the evolution of this upcoming market?
 How is the current and future market opportunity likely to be distributed across key market segments?

The financial opportunity within the SARM1 targeting therapeutics market has been analyzed across the following segments:

 Type of Molecule
 Small Molecules
 Biologics

 Target Indication
 Multiple Sclerosis
 Peripheral, Central and Ocular Nervous System Disorders
 Peripheral Neuropathies
 Glaucoma
 Amyotrophic Lateral Sclerosis

 Drug Developers
 Company 1
 Company 2
 Company 3

 Drug Candidates
 Drug Candidate 1
 Drug Candidate 2
 Drug Candidate 3
 Drug Candidate 4
 Drug Candidate 5
 Drug Candidate 6

 Key Geographies
 North America
 Europe

The research includes detailed profiles of key players (listed below); featuring an overview of the company, financial information (if available), details related to its product portfolio, patent portfolio, recent developments (including partnerships and collaborations) and an informed future outlook.
 Disarm Therapeutics
 Nura Bio
 Washington University

For additional details, please visit
https://www.rootsanalysis.com/reports/sarm1-inhibitors-market.html
or email sales@rootsanalysis.com

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1. RNAi Market: Therapeutics and Technologies (Focus on siRNA, miRNA, shRNA and DNA) (3rd Edition): Industry Trends and Global Forecasts, 2022-2035
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About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

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The organ-on-chip market is anticipated to grow at a CAGR of 21.3% till 2035

In order to overcome the limitations and challenges related to animal testing, researchers and industry stakeholders are gradually adopting organ-on-chip products and technologies, which offer multiple benefits over conventional systems.

Roots Analysis has announced the addition of “Organ-on-Chip Market, 2022-2035: Focus on Products and Technologies” report to its list of offerings.

With the introduction of FDA Modernization Act in 2021, the use of animal models for preclinical testing is being discouraged in the pharmaceutical industry. Several players have opted to modernize their conventional testing models with organ-on a chip products and technologies. These novel products have the potential to transform the drug discovery process by simulating the human physiological and functional environment on a microfluidic system. In addition, these organ-on-chip models not only reduce the need for animal testing model but are also capable of speeding-up the research and precise evaluation of drug toxicity and cellular responses.


Key Market Insights

Around 145 organ-on-chip products and technologies are offered by 45+ players
Nearly 67% of the aforementioned products and technologies are commercialized; of these, 93% products and technologies are intended for drug discovery and toxicity testing related applications, followed by cancer research (44%), stem cell research (32%) and tissue engineering and regenerative medicine (21%).

420+ patents related to organ on a chip products and technologies were filed / granted, since 2017
Based on the intellectual property distribution across the world, R&D activity related to organ on a chip technology and product is largely concentrated in China (over 30%), followed by the US (24%). The majority of the patents in this domain were filed by non-industry players (55%).

More than 345 grants have been awarded to support the ongoing research for organ-on-chip models
Grants worth USD 167 million have been awarded to various companies / organizations working in this domain till July 2022. Further, the number of grants awarded to stakeholders in this domain (in the US) has continuously increased between 2019 and 2021. Around 20% of the grants were funded by the National Center for Advancing Translational Sciences.

Partnership activity in this domain has increased at a significant pace, between 2017 and 2022
The maximum number of partnerships were established in 2020 and 2021 (21, each), indicating a recent rise in the interest of players engaged in this domain. It is worth highlighting that the majority of the deals were technology / product utilization agreements, representing around 30% of the total number of partnerships signed in the given time period.

Amount worth over USD 680 million was invested by both private and public investors in this domain, since 2017
Of the total amount invested, around USD 385 million was raised through grants / awards, representing around 55% of the overall funding activity in this domain. Further, 13 instances of venture capital financing were also reported, wherein players collectively raised more than USD 215 million.

North America and Europe are anticipated to capture over 75% of the market share by 2035
The market in Asia-Pacific and Rest of the World are anticipated to grow at a relatively faster rate to occupy overall 24% of the total market. In addition, it is worth noting that organ(s) based models are likely to capture more than 70% of the market.


To request a sample copy / brochure of this report, please visit this https://www.rootsanalysis.com/reports/organ-on-a-chip-market/request-sample.html

Key Questions Answered
 Who are the leading players engaged in the development of organ-on-chip products and technologies?
 What are the different application areas of organ-on-chip products and technologies?
 Which are the key geographies where organ-on-chip developers are located?
 How has the intellectual property landscape of organ-on-chip evolved over the years?
 Which partnership models are commonly adopted by stakeholders in the organ-on-chip domain?
 What are the investment trends and who are the key investors actively engaged in the organ-on-chip domain?
 How is the current and future opportunity likely to be distributed across key market segments?


The financial opportunity within the organ-on-chip market has been analyzed across the following segments:
 Type of Product
 Organ(s) based
 Disease(s) based

 Type of Application Area
o Drug Discovery and Toxicity Testing
o Cancer Research
o Tissue Engineering and Regenerative Medicine
o Stem Cell Research

 Purpose
o Research Use
o Therapy Development

 Key Geographical Regions
o North America
o Europe
o Asia-Pacific
o Rest of the World (RoW)

The opinions and insights presented in the report were influenced by discussions held with senior stakeholders in the industry. The report features detailed transcripts of interviews and surveys held with the following industry players:
 Michael Shuler (President, Hesperos)
 Matt Dong-Heon Ha (Chief Executive Officer, EDmicBio)
 Jelena Vukasinovic (Chief Executive Officer, Lena Biosciences)
 Maurizio Aiello (Chief Executive Officer, react4life)
 Michele Zagnoni (Chief Executive Officer, ScreenIn3D)
 Pierre Gaudriault, (Chief Business Development Officer, Cherry Biotech)

The report includes detailed profiles of key players (listed below), engaged in the development of organ-on-chip products and technologies; each profile features an overview of the developer, product portfolio and recent developments, and an informed future outlook:
 BEOnChip
 Dynamic42
 Emulate
 MIMETAS
 SynVivo
 TissUse
 uFluidix

For additional details, please visit https://www.rootsanalysis.com/reports/organ-on-a-chip-market.html or email sales@rootsanalysis.com

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1. 3D Cell Culture Market (4th Edition): Industry Trends and Global Forecast, 2022-2035
2. Artificial Intelligence in Oncology Market: Industry Trends and Global Forecast, 2022-2035
About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
ben.johnson@rootsanalysis.com

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