Monkeypox: Disease Overview, Transmission and Diagnosis

Monkeypox is a viral disease, which is usually transmitted to humans from animals. The disease is known to have symptoms similar to those observed in smallpox patients, although it is considered to be clinically less severe.

In recent years, monkey pox has emerged as a prominent orthopox virus affecting public health. In May 2022, multiple cases of the disease were reported in more than 100 non-endemic countries, thereby making monkeypox a disease of global concern. Consequently, in July 2022, the World Health Organization (WHO) declared global monkey pox outbreak a Public Health Emergency of International Concern (PHEIC). In fact, till date, over 84,000 cases of the disease have been reported, globally.


Monkeypox infection can be divided into two periods:
1. Invasion Period (0 to 5 days): This phase is characterized by fever, intense headache, lymphadenopathy (swelling of the lymph nodes), back pain, myalgia (muscle aches) and intense asthenia (lack of energy)
2. Skin Eruption (begins within 1 to 3 days of appearance of fever): Monkeypox rash affects the face (in 95% of cases), palms of the hands and soles of the feet (in 75% of cases). Oral mucous membranes (in 70% of cases), genitalia (30%), and conjunctivae (20%), as well as the cornea are also affected.

Monkeypox Disease Transmission
Monkeypox virus can be transmitted from animals to humans as well as from humans to humans.
 Animals to Humans Transmission:
Zootnotic transmission can occur from direct contact with the bodily fluids, blood or cutaneous / mucosal lesions of infected animals. Additionally, eating inadequately cooked meat and other animal products of infected animals is a possible risk factor.
 Humans to Humans Transmission:
Human-to-human transmission can result from close contact with respiratory secretions, skin lesions of an infected person or recently contaminated objects. Transmission can also occur via the placenta from mother to fetus or during close contact during and after birth.

Monkeypox Disease Diagnosis
Polymerase chain reaction (PCR) is the preferred laboratory test for monkey pox virus detection due to its accuracy and sensitivity. Optimal diagnostic samples for monkey pox diagnosis are collected from skin lesions; these include roof or fluid from vesicles and pustules, and dry crusts. Additionally, biopsy samples can also be collected for disease diagnosis.

Conclusion
With only a few therapeutics / vaccines currently approved or granted special access for the monkeypox treatment / prevention, the existing demand for effective monkeypox vaccines and therapeutics is still unmet. In response to the monkey pox outbreak, active research and development efforts are underway to develop various therapeutics and vaccines for the treatment and prevention of monkeypox. Presently, more than 25 therapeutics / vaccines are commercialized / under development for the treatment and prevention of monkeypox. With the increase in the number of monkeypox cases globally, the demand for testing has also increased. At present, more than 165 diagnostic kits are available in the market for the detection of monkeypox virus. The growing cases of monkeypox disease and availability of limited number of therapeutics / vaccines / diagnostic solutions are the key factors driving the growth of this market.

For additional details, please visit
https://www.rootsanalysis.com/blog/monkeypox-disease-overview/ or email sales@rootsanalysis.com

You may also be interested in the following titles:
1. Smart Labels Market: Industry Trends and Global Forecasts, 2022-2035
2. AI-based Digital Pathology / AI Pathology Market: Industry Trends and Global Forecasts, 2022-2035

About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

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CAR-T Cell Therapies: Addressing Key Unmet Needs Across Various Oncological Indications

Amidst the active initiatives undertaken to develop more targeted anti-cancer therapies, CAR-T therapies have emerged as a promising option, given their ability to eradicate tumor cells from the body with minimal treatment-related side effects.

Further, CAR-T cell therapies, relatively recent addition to the gamut of anticancer interventions, has demonstrated significant promise. Overall, this highly specific and promising form of CAR-T cell therapy treatment, which harnesses the versatile effector machinery of the human immune system, has revolutionized cancer treatment, globally. Given the consistent increase in number of cell therapies being developed and launched, this upcoming therapeutic segment is on its way to becoming one of the highest valued markets within the biopharmaceutical industry.
At present, more than 5 CAR-T therapies have been approved for several hematological malignancies, including KYMRIAH® (Novartis), YESCARTA® (Gilead Sciences), TECARTUS™ (Gilead Sciences), Breyanzi® (Bristol Myers Squibb), Abecma™ (Bristol Myers Squibb) and CARVYKTI™ (Janssen Biotech / Legend Biotech). In fact, more than 170 companies are engaged in the development of over 970 early and late-stage CAR-T therapies, worldwide. Moreover, several promising leads are anticipated to be commercially launched over the coming decade, following which the market is projected to grow at a substantial pace.
Over 6,500 patents related to CAR-T cell therapies have been recently filed / granted, demonstrating the continued innovation in this domain. In addition, more than 260 collaborations have been inked between several industry / academic stakeholders in order to advance the development of various pipeline candidates. To fund product development initiatives, capital investments worth more than USD 24 billion have been made by various private and public sector investors, in the last few years. Driven by the ongoing pace of innovation in this field, sufficient financial support from investors and encouraging clinical trial results, the CAR-T cell therapies market is likely to witness significant growth in the foreseen future.
CAR-T Cell Therapies, With Over 970 Preclinical / Clinical Candidates, Represent One of The Most Active Segments Of The Pharmaceutical Domain
Majority (82%) of the CAR-T cell therapies are being developed using autologous T-cells, followed by those using allogeneic cells, derived from the blood of healthy donors. It is worth highlighting that majority of these CAR-T therapies are monotherapies (92%) followed by combination therapies. Additionally, most of the therapies being developed for the treatment of acute lymphoblastic leukemia, B-cell lymphoma, multiple myeloma, non-Hodgkin lymphoma and acute myeloid leukemia using several target antigens which includes CD19, BCMA, CD22, CD20, Meso, and CD7.
A Rise In Partnerships, In The Recent Past, Involving Both International And Indigenous Stakeholders, Validate The Growing Interest In This Domain; Maximum Number Of Such Deals Were Signed In 2021
Since 2015, the partnership activity in this domain has increased significantly. Given that most of the products are commercially available, in recent years, numerous agreements for product evaluation have been inked. Majority of partnerships are licensing agreements followed by R&D agreements (21%); most of the licensing deals (68%) are focused on technology licensing for the development of CAR-T therapies.
Several Investors, Having Realized the Opportunity Within This Upcoming Segment, Have Invested Close To USD 25 Billion
More than 65% of the total funding amount was invested in the last five years. Specifically, in 2022 so far, companies engaged in this domain have collectively raised more than USD 7 Billion, majority of the funding was acquired through venture capital rounds, other equity financing elements and secondary offerings.
Over 6,500 Patents Related to Car-T Therapies Have Been Recently Filed / Granted, Demonstrating The Continued Innovation In This Domain
Majority of the patents related to CAR-T cell therapies have been filed by non-industry players; more than 1,400 such patents were filed in 2021 alone. Additionally, most of the patents in this domain are patent applications (84%), followed by granted patents (13%) and Others (3%).
The Projected Opportunity for Car-T Cell Therapies Is Likely to Be Well Distributed Across Different Segments And Is Estimated To Grow At An Annualized Rate Of 20%, Till 2035
The global CAR-T cell therapy market is estimated to be worth USD XX billion in 2022, and this value is projected to reach around USD XX billion in 2035, growing at a CAGR of 20%, during the period 2022-2035. In the long-term, the overall projected opportunity is likely to be well distributed across key market segments, including target indications, target antigen, key players and geographical regions.
For additional details, please visit
https://www.rootsanalysis.com/blog/car-t-cell-therapies-addressing-key-unmet/ or email sales@rootsanalysis.com

You may also be interested in the following titles:
1. 4D Bioprinting Market, 2023-2035
2. Non-Viral / Intracellular Drug Delivery Systems Market, 2023-2035

About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

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Exploring How Artificial Intelligence Is Transforming Digital Pathology

Digital pathology is a transformative technology that has enabled pathologists to make the shift from visual inspection of tissue samples to automated image analysis.

With the advent of AI, pathologists are now benefiting from computerized image analysis software that can draw conclusions and deliver diagnoses in a fraction of the time. Now, pathologists can analyze the RNA / DNA or protein expression of a sample, which is far more accurate than visual analysis. AI is being used to analyze images and extract meaningful information from them, to automate tedious tasks, and to create new ways of diagnosing and treating diseases. Pathologists can rely on AI to extract features from images and classify them into appropriate categories for diagnosis.

Benefits of AI in Digital Pathology
AI is revolutionizing digital pathology by improving accuracy, consistency, and operational efficiency. AI is improving accuracy by enabling pathologists to derive more insights from images and improving the consistency of results by reducing bias. AI-driven analysis is repeatable and consistent, leading to more accurate diagnoses. AI is also improving operational efficiency by automating and optimizing workflows. Pathologists can now rely on AI to manage their workflows, reducing the time spent on tedious tasks.

AI-Based Automation of Pathology Workflows
AI is transforming pathology workflows by automating processes and optimizing collaboration among team members. Pathologists can now leverage AI to manage their workflows, helping to optimize workflow operations. AI can be used to automate processes like image acquisition, data management, and report formatting, as well as recordkeeping tasks.

With AI, pathologists can collaborate more effectively with other team members by sending them notifications on issues, such as abnormal test results or abnormal exam findings. AI can be used to facilitate collaboration between pathologists and other health care professionals, such as researchers and clinicians. Pathologists can send images and findings to researchers for further analysis.

AI-based digital pathology process
 Preparation of Tissue Sample
 Converting into Virtual Sample / Whole slide imaging (WSI)
 Saving a Virtual Slide
 Viewing and Editing of Slide
 Sharing Data
 Reporting Results

AI-Driven Automated Diagnosis & Treatment
New AI technology is allowing pathologists to make diagnoses and prescribe treatments using a machine-generated narrative. AI is being used to analyze images and extract meaningful information from them, enabling pathologists to make more accurate decisions about diagnoses. AI can be used to analyze tissue samples as well as blood and urine samples to derive a more accurate diagnosis.

New AI technology is allowing pathologists to make diagnoses and prescribe treatments using a machine-generated narrative. AI can be used to analyze images and extract meaningful information from them, enabling pathologists to make more accurate decisions about diagnoses. AI can be used to analyze tissue samples as well as blood and urine samples to derive a more accurate diagnosis.

AI in Enhancing Accessibility & Efficiency of Digital Pathology
AI is helping to make digital pathology more accessible, efficient, and reliable. With AI, pathologists can now access more accurate data and insights in a fraction of the time. AI-driven solutions are able to understand and interpret complex data, making them highly accessible and efficient. AI is helping to make digital pathology more reliable by minimizing errors in data analysis. AI is being used to analyze images and extract meaningful information from them, enabling pathologists to make more accurate decisions about diagnoses.

Challenges for AI in Digital Pathology
With the advent of AI, digital pathology is being transformed from visual inspection to molecular analysis. However, there are some challenges associated with AI in digital pathology. The first challenge is the cost of implementation. For organizations to benefit from AI-driven solutions, they have to invest in the technology and hire AI experts to put the technology to use. The second challenge is the lack of understanding of AI by both pathologists and patients. Pathologists are not well-versed with AI and its capabilities, and patients are not aware of the role of AI in pathology, which may lead to inaccurate conclusions.

Conclusion
Digital pathology is transforming the traditional pathology workflow by enabling pathologists to make better, more accurate diagnoses through automated image analysis. With the advent of AI, digital pathology is now able to analyze images and extract meaningful information from them, enabling pathologists to make more accurate decisions about diagnoses. With AI, pathologists can now access more accurate data and insights in a fraction of the time, making it easier for them to make correct decisions about patient care, treatment, and prognosis.

For additional details, please visit
https://www.rootsanalysis.com/blog/how-artificial-intelligence-transforming-digital-pathology/ or email sales@rootsanalysis.com

You may also be interested in the following titles:
1. Smart Labels Market: Industry Trends and Global Forecasts, 2022-2035
2. 4D Bioprinting Market : Industry Trends and Global Forecasts, 2022-2035


About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

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The smart pharmaceutical and healthcare labels market is anticipated to grow at a CAGR of 16%, till 2035, claims Roots Analysis

In order to overcome the limitations and challenges related to counterfeit drugs, researchers and industry stakeholders are gradually adopting smart pharmaceutical and healthcare labels, which offer multiple benefits over conventional labels.

Roots Analysis has announced the addition of “Smart Pharmaceutical and Healthcare Labels Market, 2022-2035” report to its list of offerings.

A smart label comprises of printed information, a bar code identifier and a small transponder. This transponder contains a processing chip and an antenna that allows physical objects to communicate with the tag reader (for instance, RFID reader). Smart labels offer several benefits, such as tracing and tracking products in a supply chain, tamper proofing, as well as discouraging counterfeiters from packaging fake drugs. In this context, it is worth mentioning that smart labelling technology can potentially save USD 0.8 - 1.5 million per year, per company, through their applications in inventory management.


Key Market Insights

More than 90 companies claim to offer smart pharmaceutical and healthcare labels, globally
This segment of the industry is dominated by the presence of mid-sized (51-500 employees) and small (less than 50 employees) players, which collectively represent more than 75% of the total smart label providers in pharmaceutical and healthcare sectors. Further, ~20% of firms were established post-2010.

400+ patents related to smart pharmaceutical and healthcare labels were filed / granted, since 2015
Based on intellectual property distribution across the world, R&D activity related to smart pharmaceutical and healthcare labels is largely concentrated in North America (over 65%), followed by Europe (10%). In addition, most of the patents have been granted patent (55%), followed by patent applications (44%).

Partnership activity in this domain has increased at a significant pace, between 2018 and 2022
The recent partnerships trend in this market indicates the growing interest of industry stakeholders. It is worth highlighting that majority of the deals were service alliances, representing around 41% of the total number of partnerships signed in the given time period.

North America and Europe are anticipated to capture over 65% of the market share by 2035
The markets in Asia-Pacific and Latin America are anticipated to grow at a relatively faster pace. In the long-term, the aforementioned regions are expected to collectively represent 33% of the total market share. In addition, RFID based smart labels are likely to capture more than 75% of the market share in 2035.

To request a sample copy / brochure of this report, please visit this https://www.rootsanalysis.com/reports/smart-labels-market/request-sample.html

Key Questions Answered
 Who are the leading players engaged in the development of smart pharmaceutical and healthcare labels?
 What is the relative competitiveness of different smart pharmaceutical and healthcare labels providers?
 Which types of partnership models are most commonly being adopted by stakeholders engaged in this domain?
 What are the key strategies that can be implemented by emerging players / start-ups to enter the highly competitive market for smart labels for the healthcare sector?
 Which companies are actively filing patents to drive innovation in the field of smart pharmaceutical and healthcare labels?
 What are the key challenges within the smart pharmaceutical and healthcare labels market?
 What is the current / likely future market size of smart pharmaceutical and healthcare labels?


The financial opportunity within the smart pharmaceutical and healthcare labels market has been analyzed across the following segments:

 Type of Technology
 RFID
 NFC
 Other Technologies

 Type of packaging
 Primary Packaging
 Secondary Packaging

 Type of Primary Packaging
 Vials
 Syringes
 Cartridges
 Ampoules
 Bottles
 Blister Packs

 Type of Secondary Packaging
 Boxes
 Cartons
 Pouches

 Key Geographical Regions
 North America
 Europe
 Asia-Pacific
 MENA
 Latin America

The report includes detailed profiles of key players (listed below) engaged in providing smart pharmaceutical and healthcare labels; each profile features an overview of the developer, details related to smart labels focused product portfolio, recent developments and an informed future outlook:
 CCL Industries
 Schreiner
 Datalogic
 Tadbik
 SATO
 Invengo
 Intellhydro Technology
 RFiD Discovery
 ID Tech Solutions

For additional details, please visit https://www.rootsanalysis.com/reports/smart-labels-market.html or email sales@rootsanalysis.com

You may also be interested in the following titles:
1. Pharmaceutical Secondary Packaging Market: Industry Trends and Global Forecast, 2022-2035
2. AI-based Digital Pathology / AI Pathology Market: Industry Trends and Global Forecasts, 2022-2035
About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
ben.johnson@rootsanalysis.com

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The TCR-based therapy market is projected to grow at an annualized rate of 51%, claims Roots Analysis

Given the recent approval of a TCR-based therapy, industry stakeholders have initiated several R&D efforts focused on evaluating the potential of such therapy candidates against various disease indications

Roots Analysis has announced the addition of “Global TCR-based Therapy Market (2nd Edition), 2022-2035” report to its list of offerings.
Modified T-cell receptor therapy (TCR therapy) is an emerging class of adoptive therapy that employs genetically modified lymphocytes to target specific tumor markers. Growing burden and unaddressed complex treatment needs of cancer patients have paved the way for more effective, safe and versatile alternatives, such as TCR therapies. Driven by Kimmtrak® approval, promising development pipeline and encouraging clinical trial results, the TCR-based therapy market is anticipated to witness significant growth in the mid to long-term

Key Market Insights
Over 190 TCR-based therapies are currently approved / under development
Close to 45% of the aforementioned candidates are being evaluated in clinical trials (phase I and above), while 30% of them are in preclinical stage of development. More than 90% of the therapy candidates, which are being developed to target a range of disease indications, are autologous in nature. Further, NY-ESO-1 and MAGE have emerged as the most popular target antigens.

More than 7,000 patients have been enrolled in nearly 110 clinical trials, worldwide
Clinical research activity, in terms of number of trials registered, is reported to have increased over the last five years. Of the total number of trials, close to 65% are active and still recruiting patients, while close to 26% have already been completed.

Partnership activity within this domain has grown at a CAGR of 27%, between 2015 and 2021
More than 70 agreements have been inked in the last 5 years. Majority of partnership deals signed within this domain were R&D agreements (26%), licensing agreements (21%), and product development and commercialization agreements (16%).

Over 11.2 USD billion has been invested by both private and public investors in this domain, since 2007
Specifically, in 2020 and 2021, industry players raised over USD 2.7 billion. In addition, majority (39%) of the companies primarily received funding through venture capital rounds. Further, around 70% of the total funding instances were reported by players headquartered in the US.

More than 70 patents have been filed / published related to the TCR-based therapies
Close to 85% of the filed / published patents were patent applications, while around 15% were granted patents and others. Of the total granted applications, close to 45% were filed in North America and Europe.

The market is anticipated to grow at a CAGR of 51%, during the period 2022-2035
In 2035, close to 60% of the market revenues are expected to be generated from sales of therapeutics intended for Nasopharyngeal Carcinoma and Multiple Myeloma. Further, therapies targeting for NY-ESO-1 are expected to occupy a larger share (~50%) of the overall market in 2035.

To request a sample copy / brochure of this report, please visit
https://www.rootsanalysis.com/reports/tcr-based-therapies-market/request-sample.html

Key Questions Answered
 What is the growth rate of TCR-based therapy market?
 Which region has the highest growth rate in the TCR-based Therapies market?
 Who are the leading industry and non-industry players in this market?
 How many players are developing TCR-based Therapies?
 Which target indication covers the largest TCR-based therapy market share?
 What is the partnership and collaboration trend in the TCR-based therapy domain?
 What is the current IP landscape of TCR-based therapies market?

The financial opportunity within the TCR-based therapies market has been analyzed across the following segments:
 Target Indication(s)
 Nasopharyngeal Carcinoma
 Multiple Myeloma
 Head and Neck Carcinoma
 Sarcoma, Melanoma
 Acute Myeloid Leukemia
 Lung Cancer
 Ovarian Cancer
 Merkel Cell Cancer

 Target Antigen
 NY-ESO-1
 EBV
 gp100
 Others

 Key Geographical Regions
 North America
 Europe
 Asia Pacific
 Latin America
 Middle East and North Africa
 Rest of the World

The report features inputs from eminent industry stakeholders, according to whom, T-cell immunotherapies are expected to be the next big step in cancer immunotherapy. The report includes detailed transcripts of discussions held with the following experts:
 Vincent Brichard (Vice President, Immuno-Oncology, Celyad)
 Adrian Bot (Vice President, Scientific Affairs, Kite Pharma)
 Victor Lietao Li (Co-Founder and Chief Executive Officer, Lion TCR)
 Miguel Forte (Former Chief Operating Officer, TxCell)

The report includes brief profiles of key players (listed below); each profile features an overview of the company, details related to its financial information (if available), details about TCR-based product(s), such as information on type of therapy and current development status, information on technology portfolio (if available), recent developments related to TCR-based therapies and manufacturing capabilities of the players.
 Adaptimmune Therapeutics
 Alaunos Therapeutics
 Bristol Myers Squibb
 Cellular Biomedicine Group
 Gilead Sciences
 GlaxoSmithKline
 Immatics
 Immunocore
 Lion TCR
 Takara Bio
 Zelluna Immunotherapy

For additional details, please visit https://www.rootsanalysis.com/reports/tcr-based-therapies-market.html or email sales@rootsanalysis.com
You may also be interested in the following titles:
1. Global T-Cell (CAR-T, TCR, and TIL) Therapy Market (6th Edition), 2022- 2035
2. mRNA Therapeutics and mRNA Vaccines Market (2nd Edition), 2022-2035

About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.


Contact:
Ben Johnson
+1 (415) 800 3415
ben.johnson@rootsanalysis.com

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